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Marreiro DD, Geloneze B, Tambascia MA, Lerario AC, Halpern A, Cozzolino SMF

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Tirzepatide provides exogenous GLP-1 receptor agonism at pharmacological concentrations

Finally, a cell cycle-dependent variation of the amount of GSTP1-1-TRAF2 complex existing in cells was detected, with a maximum in G 0 /G 1 and a strong decrease in S, G 2 , and M phases

GLP-1R was found in 83% of the activated PSCs

While non-modifiable risks like age, gender, and genetics are well-known, emerging evidence underscores that obesity, metabolic syndrome, and gut dysbiosis are potent, modifiable risk factors, intricately linked to daily dietary patterns (8, 9)