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Children with ASD also have significant decreases in methionine levels and the ratio of plasma S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) (SAM: SAH ratio), an index of methylation capacity ( Most importantly, children with ASD also have decreased levels of total glutathione and the reduced or active form of glutathione ( Although prior nutritional interventions addressing antioxidant capacity have successfully improved glutathione levels, the association between these changes and autistic behavior has been less compelling

This has led to the hypothesis that elevations in GGT reflect increasing xenobiotic-GSH conjugation, including POPs,with preliminary evidence linking GGT levels to polycyclic aromatic hydrocarbon exposure

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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Cani P.D., Bibiloni R., Knauf C., Waget A., Neyrinck A.M., Delzenne N.M., Burcelin R

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