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A meaningful share of participants achieved weight-loss levels previously associated primarily with bariatric surgery

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Studies have shown that GLP-1RA affects the key phases by reducing its main cytokines and chemokines, such as TNF, IL-6, IL-10, and IL-12, and MCP-1, leading to a reduced inflammatory state, improved endothelial function, and promoted cholesterol efflux

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The first-line treatment according to the American Psychiatric Association remains naltrexone or acamprosate, combined with behavioral support

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