Bigger doses might actually slow us down for a bunch of reasons
In particular, poly(I:C), a synthetic viral RNA mimic, increased GLP-1 release in mice [1-2]
And the honest answer is: what you eat on GLP-1 therapy matters more than most people realize
Importantly, although GLP-1(2836)driven ATP generation was retained in caSMCs isolated from sAC / mice (Figure 4C), cells lacking sAC could not generate cAMP in response to this stimulus (Figure 4D)
It has multiple effects: it signals the pancreas to produce more insulin and, importantly for weight loss, it acts on the brain to suppress appetite and increase feelings of fullness
Firstly, the way that the different drug concentration varies over time seems to play a part, for some people at least, in the short term effectiveness of it