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[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories

In some cases, temporary dose reduction or pausing dose escalation of the GLP-1 medication may be appropriate while nutritional status is optimized, though this decision should be made collaboratively between patient and provider

Developing and testing targeted interventions based on the findings to improve medication adherence would be a logical next step in this research

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For practitioners treating GLP-1 non-responders, this evidence suggests a paradigm shift in intervention timing