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Barbara Kahn of Harvard Medical School, this relationship was one of the original reasons NNMT was studied as a possible regulatory factor in obesity and metabolic imbalance

Without L-carnitine, these dietary fats cannot enter the mitochondrial matrix to undergo beta-oxidation, the biochemical process that breaks down fats to generate adenosine triphosphate (ATP), the universal energy currency of the human body

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These cognitive benefits occurred without major changes in blood glucose or body weight, indicating the effect was central (brain-related) rather than due to improved metabolic control