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35,36 While the subsequent GUIDE-HF trial did not find a difference in cardiovascular outcomes using PA pressure monitoring, a newly published trial based out of Europe, MONITOR-HF, demonstrated findings similar to the earlier CHAMPION trial that PA pressure monitoring to guide HF management reduced HF-related hospitalizations and improved quality of life

yet, it remains a double-edged sword, as chronic high levels are notorious for promoting cachexia(2)the severe muscle wasting often seen in late-stage cancer