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Semaglutide, TRT, and Erectile Dysfunction Theres speculation (especially on Reddit) that semaglutide causes ED
Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor
However, experts quoted in a July 29 PBS article warned that these supplements do not come close to matching the effectiveness of real GLP-1 agonists such as semaglutide (sold under the brand names Ozempic and Wegovy) and tirzepatide (sold as Mounjaro and Zepbound)
For example, liraglutide has been shown to improve neural function through multiple signaling pathways, whereas semaglutide appears to exert more pronounced effects on neuroinflammation and neural tissue remodeling [11, 84, 86]
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Jing F, Zou Q, Wang Y, Cai Z, Tang Y (2021) Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation
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