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Nodose sensory neurons have also been implicated in the regulation of alcohol consumption [163], although few studies have directly investigated peripheral sensory mechanisms of alcohol reinforcement

We found that intracellular 1-MNA and NNMT protein expression levels were substantially higher in the fully differentiated adipocytes compared to the undifferentiated pre-adipocytes, which is consistent with the differentiation-dependent enhancement in NNMT mRNA levels and enzymatic activity reported previously in the 3T3-L1 cell lines.[37] The higher levels of 1-MNA and NNMT in adipocytes compared to pre-adipocytes may partially account for our observations that increasing concentrations (10 60 M) of NNMT inhibitor did not completely eliminate 1-MNA in adipocytes, but did fully suppress 1-MNA accumulation in undifferentiated pre-adipocytes

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[DOI] [PubMed] [Google Scholar] [232].Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I

Cooperrider J, Furmaga H, Plow E, Park H-J, Chen Z, Kidd G, et al

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