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This is most likely mediated via a humoral route based on increased availability of its precursor tryptophan in the plasma [231]

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In CRC, SQOR expression and function show significant stage specificity and duality

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The composition of immune infiltrate varies with disease stage and patient age, but mostly, CD3 + T cells, CD4 + T cells, CD20 + B cells, and macrophages are found [117]

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