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Additionally, GLP-1 RAs modulate the hypothalamus (the region in the brain that controls appetite) to regulate hunger, slow gastric emptying, and regulate gut hormones such as leptin (a hormone that helps regulate body weight on a long-term basis)

However, this comparison is imperfect because tirzepatide at these doses typically produces more weight loss than semaglutide at corresponding doses

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[DOI] [PubMed] [Google Scholar] 113.Hernndez T, Palafox C, McFadden K, Ramsberger G, Rings J