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Thus, the use of this approach allowed to identify an original target, the protein kinase DYRK1B, suggesting that an inhibitor of this protein could present a possible senolytic activity 40

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National LIbrary of Medicine

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Summary of ongoing and planned clinical studies of GLP-1-RAs in psychiatric populations or related to mental health outcomes)

Understanding this difference helps clarify why dose increases alone sometimes fail to restore the original effect, and why alternative strategieslike medication rotation or genetic optimizationmay be necessary