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Genetic mutations in genes codifying for the cytochrome c oxidase are related to fatal metabolic disorders [64] which particularly affect tissues and organs with high energy demand, such as the heart

1 Introduction Atopic dermatitis (AD) is a chronic, recurrent, inflammatory, pruritic dermatosis with complex pathophysiology, involving disruption of the epidermal barrier, microbial dysbiosis within affected lesions, and Th2 immune responses to skin allergens ( Obesity, a major health problem, is a result of metabolic syndrome in adipose tissue and is linked to various chronic immune disorders ( Currently, the association of obesity/overweight with AD is not conclusive

Lancet (2010) 376(9739):4319

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These improvements result from both direct drug effects and the metabolic benefits of weight loss

doi: 10.1542/peds.2014-0376 110