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Incretin-based therapies improve glycemic control in obese individuals with T2D [169, 170], and may also be an alternative approach to treat GDM

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Its label also includes cardiovascular risk reduction for certain adults, and it recently added an indication for adults with noncirrhotic MASH (metabolic dysfunction-associated steatohepatitis) and moderate to advanced fibrosis

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While not yet FDA-approved as a standalone agent, cagrilintide peptide therapy is being investigated for: Obesity treatment Metabolic syndrome management Adjunctive therapy for GLP-1 agonist non-responders Research in combination with emerging agents like retatrutide Note: As of 2025, cagrilintide is still considered a research compound in many jurisdictions