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[DOI] [PMC free article] [PubMed] [Google Scholar] 172.Rastrelli G., Corona G., Sparano C., Vignozzi L., Sforza A., Maggi M

[7] [8] Additional risk factors include renal impairment, which can alter medication clearance and glucose homeostasis, and hepatic dysfunction, which affects gluconeogenesis and glucose regulation

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Skipping meals, meal timing, portion size, intake speed, nutritional make up, and fluid ingestion patterns are all potential side effect modifiers

But in Pearsons study, the genetic alterations werent connected with weight loss, meaning the effect was probably limited to the pancreas