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Only one recent study has repor ted the presence of colonic inflammation in mice.52 The mucosal surface is implicated in the protection against inflammation process and the decrease in mu- cus-producing cells and the loss of epithelial integrity could gener- ate mucosal inflammation.6Thetrea tm entwi thGA AEory ohimb ine improved the epithelium integrity and increased the mucus-produc- ing cells

Ondansetron and semaglutide do not have direct drug interactions, but daily ondansetron use is typically recommended only for short-term nausea (a few days to one week)

Both medications independently affect stomach lining integrity and nausea risk, making concurrent use a clinical consideration requiring provider oversight

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Hp is known to stimulate COX-2 expression and also to increase PGE2 synthesis (90) that could be an important factor by which CagA positive Hp strains could increase the risk of GC ( Fig