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Synthesis and Secretion of GLP-1 and GIP K-Cell (jejunum) L-Cell (ileum) ProGIP Proglucagon GIP [1-42] GLP-1 [7-37] GLP-1 [7-36NH2] 100 | 20 | 40 | 100 | 160 80 15 60 10 40 Intact GIP (pmol/L) Intact GLP1 (pmol/L) 5 20 0 0 | 20 | 40 | 100 | 160 Time (min) Time (min) Secretion of Incretins After Meals GIP GLP1 50 200 40 150 30 100 Total GLP1 (pmol/L) Total GIP (pmol/L) 20 50 10 0 0 20 Vilsboll T, et al
GLP-1 receptor agonists do their work by playing a sort of trick on the body, and the body doesnt always like it
Kreymann B, Ghatei MA, Williams G, Bloom SR
It does mean the evidence base for a specific compounded preparation is different from the evidence base for an FDA-approved finished drug product
Conclusion: First line use of SGLT2i and GLP-1RAs is effective in reducing HbA1c, weight, and FPG levels in T2DM patients at low risk for cardiovascular disease
References Aroda, V
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