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40 Preclinical studies have shown that these effects are mainly mediated trough the effects of GLP-1R activation in the central nervous system (CNS) by the modulation of orexigenic and anorexigenic signaling pathways

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Summary: Current evidence does not establish that GLP-1 medicines cause cancer in humans, despite theoretical concerns from animal studies

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GLP-1 receptor agonists have been found to increase SHBG levels in patients with polycystic ovary syndrome [32]

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