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Retatrutide is engineered as a single synthetic peptide that simultaneously activates three hormone receptors GLP-1, GIP, and glucagon whereas currently approved medicines target only one or two of these pathways

A recent study reported that GLP-1RA liraglutide ameliorated DSS-induced colitis by modulating ILC3s and that GLP-1RA promoted IL-22 production by ILC3s, which ameliorated histological damage [185]

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