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It is an episodic monoarthritis (polyarthritis in 10% of cases) Initially it was thought that gout happened due to excessive formation of uric acid but later on it became clear that it was mainly due to insufficient clearance by kidneys

Genetics -women whose mothers developed stretch marks are far more likely to get them as well

Environmental factors Various types of environmental factors were shown to influence adipogenesis

The Lancet, 391(10118), 309318

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To investigate whether these effects of MT were mediated via TRIP13, we used a TRIP13 knockout cell line to detect relative protein expression levels