Tolerability (preclinical): Each peptide is generally well tolerated in animal studies, with occasional mild injection-site reactions
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gingivalis , synergistically drives ferroptosis in periodontal cells through multidimensional virulence factors, including lipopolysaccharide, gingipains, and the metabolic end product butyrate ( At the immunological level, lipopolysaccharide significantly downregulates SLC7A11 expression by activating the TLR4/NF-B pathway, thereby limiting cysteine uptake and depleting the glutathione pool ( Mitochondria represent another critical target
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Sodium-glucose cotransporter protein 2 inhibitors (SGLT2-I) are oral anti-diabetic medications that lower blood sugar by lessening the kidneys proximal convoluted tubules renal glucose reuptake [27]