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A full validation of the methods was performed according to the current guidelines

Superimposing the TMD of GLP-2R with that of GLP-1R shows that the intracellular portions of both receptors, except ICL2 and ICL3, overlap very well, whereas the extracellular parts of TM1, TM5 and TM7 as well as all ECLs have different conformations and side-chain orientations (Fig

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