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While effective, injections require medical supervision, can be costly, and carry risks like infections or allergic reactions

doi:10.1074/jbc.M806122200

DNA damage and cellular senescence (stasis) also contribute, as melanocytes and their stem cells gradually lose function

According to NICE Clinical Knowledge Summaries, the health consequences of untreated B12 deficiencyincluding irreversible neurological damage, megaloblastic anaemia, and cognitive impairmentfar outweigh the inconvenience of manageable acne