Tablets and sublingual formats lose some active ingredient to first-pass metabolism or buccal absorption variability
Regular check-ins with a healthcare provider guide progress and support safety
SURMOUNT-5 trial data (2025) and broader real-world reports indicate tirzepatides dual GIP/GLP-1 mechanism produces appetite suppression comparable to or faster than semaglutide at equivalent weight-loss doses
They provide protein and healthy fats, nutrients that support feeling full after meals
If you plan to choose brand-name semaglutide, you can consult with Sequence clinicians to get the medication at discounted or promotional prices
Ozempic, Wegovy, and Rybelsus are the only FDA-approved products containing semaglutide produced by Novo Nordisk, Inc., while Zepbound and Mounjaro are the only FDA-approved products containing tirzepatide produced by Lilly USA LLC