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During HCV infection, for instance, in the acute phase, the activation of the Nrf2 pathway defends infected cells from inflammatory response, while during the chronic phase its inhibition restores the oxidative imbalance, thus favouring the virus persistence [140]

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( Wiley Online Library ) Where the evidence is still a bit thin Topical anti-wrinkle outcomes: a 2025 review on topical GHK as an anti-wrinkle peptide points out practical limitations (like stability and penetration) and highlights that clinical studies are surprisingly limited compared to how widely its promoted

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