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Suicide in bipolar disorder patients is associated with hippocampal microglia activation and reduction of lymphocytes-activation gene 3 (LAG3) microglial checkpoint expression

Modulates nitric oxide (NO) pathways , improving circulation and reducing oxidative stress

In the 50s, when chemotherapy wasnt yet available, massive doses of B12 shots were given to children with a neuroblastoma tumor every two days, for 2-3 years with great success: NEUROBLASTOMA: AN EVALUATION OF ITS NATURAL HISTORY AND EFFECTS OF THERAPY, WITH PARTICULAR REFERENCE TO TREATMENT BY MASSIVE DOSES OF VITAMIN B12

Timing Baseline Marker CRP Why it matters May help track broader inflammation when injury, gut symptoms, or systemic inflammation are part of the picture

doi: 10.1038/s41416-020-01156-1 55 SchiliroCFiresteinBL

Cell pellet may be frozen for up to several months at 80 C