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In the past, we have performed surgeries on a small number of patients, whose results have been sub-optimal

If you do not feel a dramatic change in the first 48 hours, that is completely normal and does not mean the shot is not working

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[1] [4] Kidney Problems : Notify your provider if you experience decreased urination, swelling in legs or feet, or unusual fatigue, as these may indicate kidney function changes, particularly in the setting of dehydration from gastrointestinal adverse effects