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The American Journal of Sports Medicine

All the dosing info online is from clinical experience, animal studies, or compounding pharmacy suggestions

Patients who are pregnant or breastfeeding, patients with active malignancy, patients with certain vascular conditions where angiogenesis is a concern, and patients on specific anticoagulants may not be candidates

Its effects tend to be more targeted and often produce noticeable changes in specific problem areas within days to weeks

For context, the fat-mass reductions reported in Billon 2024 roughly 25-30% in diet-induced obese mice over 28 days without exercise are large for a preclinical metabolic agent and explain why the "exercise mimetic" label stuck

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