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Sales of a new class of weight loss drugs known as GLP-1s have transformed Eli Lilly $LLY and Novo Nordisk into the most valuable pharmaceutical companies in the world

Most importantly, they experience meaningful weight loss

The result is that many people starting these medications are caught off guard by how they feel in the early weeks, leading some to stop treatment prematurely when the side effects were actually manageable and temporary, and others to push through symptoms that warranted medical attention

Hold the cold compress against the skin for 10 to 15 minutes at a time

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Key takeaways Zepbound (tirzepatide) and Ozempic (semaglutide) are injectable GLP-1 drugs