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In SH-SY5Y cells stimulated with A 142 or 6-OHDA, DMF has been reported to increase cellular viability and reduce intracellular ROS production, both through the activation of HMOX-1, while a study treating ALS patient-derived macrophages demonstrated DMFs ability to inhibit pro-inflammatory cytokines as well as NF-kB (Table 1)

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Angiotensin-converting enzyme inhibition and angiotensin AT(1)-receptor antagonism equally improve doxorubicin-induced cardiotoxicity and nephrotoxicity

Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial