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Gu J, Liu J, Huang T, Zhang W, Jia B, Mu N, Zhang K, Hao Q, Li W, Liu W, Zhang W, Zhang Y, Xue X, Zhang C, Li M (2018) The protective and anti-inflammatory effects of a modified glucagon-like peptide-2 dimer in inflammatory bowel disease

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Many patients are referred by their primary care provider for evaluation and treatment

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Leptin is produced not only in the adipose tissue but also in the gastrointestinal tract, particularly in the stomach, where it has been shown to protect the gastric mucosa against various topical irritants and ulcerogens, acting, at least in part, via enhancement of mucosal blood flow due to increased production of nitric oxide (NO) caused by upregulation of NO synthase as well as the activation of brain-gut axis pathways (48, 49)

Semaglutide is available for both oral and subcutaneous routes