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One hypothesis is its inability to reduce key oxidative biomarkers like advanced lipoxidation end-products, molecules that indirectly show the activity of 4-HNE (Ghodsi et al., 2019)

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Additionally, CAFs have been found to secrete glycoproteins such as tenascin-C, periostin, and proteoglycans such as versican, which regulate cell adhesion and proliferation (110)

Gross and microscopic examination of tissues and organs performed on animals killed at 12 months indicated a slight increase in the severity of renal tubule vacuolation in high-dose males