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10.1038/sj.bjp.0706290 Br

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By inhibiting glucose reabsorption in the proximal tubule, these agents reduce renal hyperfiltrationa hallmark of early DKDvia tubuloglomerular feedback, thereby lowering intraglomerular pressure and albuminuria

Most adults receive between 0.2mg and 0.3mg daily, equivalent to roughly 3 micrograms per kilogram of body weight

J Neurosci 27:394655, PMID: 17428968 Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT (1989) Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress