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Review article: The gut microbiome as a therapeutic target in the pathogenesis and treatment of chronic liver disease

Therefore, if the newborn screening detects low carnitine levels, both the baby and the mother are re-tested, after two weeks, to determine who has PCD.[14] Treatment / Management The mainstay of primary carnitine deficiency involves lifelong treatment with a high dose of oral L-carnitine (100 to 200 mg/kg daily dose in 3 divided doses).[3][4] The oral bioavailability of L-carnitine is 5% to 18%.[5] L-carnitine is a fairly safe medication, and few side effects associated with high doses include diarrhea and intestinal discomfort

Subgroup analyses suggest that older adults and those with more metabolic resistance tend toward the lower end of that range, but 10 to 15 percent body weight reduction over 12 to 18 months is a realistic expectation for many patients over 50

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