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LDL r-null mice fed a choline-supplemented chow diet exhibit aggravated aortic aneurysm pathogenesis in a gut microbiota-dependent manner mediated by the generation of TMAO [66]
So in my mind, when I hear mitochondrial biogenesis, I'm like, "aging." That's the first thing I think of
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They are used as supportive therapy following clinical assessment
A multi-center phase-II clinical trial, started a few years ago to investigate the biological and clinical effects of rapamycin in people with ALS, is currently underway and will provide important information for further potential trials [312], thus opening new therapeutic perspectives for ALS