671 FRET sensors, with their inherently ratiometric nature, utilize interconnected donor as well as acceptor molecules, linked by a peptide sequence containing a zinc-binding domain
A safe serum range is 200350 ng/L, depending on age and clinical condition
in Nature Medicine demonstrated that blocking NNMT in white adipose tissue increased energy expenditure, reduced fat mass, and improved insulin sensitivity in animal models even without changes in diet or activity (Kraus et al., Nature Medicine )
A 14 C-cystine transport assay in xCT knockout (xCT-KO) cells revealed this transporter as unique and indispensible for cystine uptake, as a complete abolishment of cystine transport has been observed
Like almost all secreted proteins, insulin is synthesized while being transferred into the lumen of the endoplasmic reticulum, ER
Extracellular superoxide dismutase inhibits inflammation by preventing oxidative fragmentation of hyaluronan