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Diagnosis should include serum B12 levels interpreted in clinical context, full blood count, and where appropriate, intrinsic factor antibodies and parietal cell antibodies

We take the time to get to know our patients, offering compassionate, family-focused healthcare in a way that big clinics cant always provide

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As chronotype is potentially modifiable, future research should focus on social and lifestyle factors to optimise interventional responses

Laboratory investigation should include complete blood count, ferritin, thyroid function, and other tests based on clinical suspicion

Characteristics of the total eligible sample and those who consented are shown in Additional file 2: Table S1 alongside imputed data