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In some embodiments, the auris-acceptable penetration enhancer is a surfactant comprising an alkyl-glycoside wherein the alkyl glycoside is dodecylmaltoside, tridecylmaltoside, and tetradecylmaltoside

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By contrast, other GH-axis compounds occupy different regulatory positions: tesamorelin is FDA-approved for a narrow HIV-associated lipodystrophy indication, and sermorelin retains a special status from its prior FDA approval