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GLP-1 Receptors Exist Throughout the Body Although GLP-1 medications work in the pancreas to regulate insulin and glucagon, GLP-1 receptors are widely distributed in other areas of the body, including the brain, cardiovascular system, immune system, gut, and kidneys, says Diana Isaacs, PharmD, CDCES, an endocrine clinical pharmacy specialist in the Endocrine and Metabolism Institute at Cleveland Clinic in Ohio

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Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down