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Most clinical research, including the most recent reviews of the literature, has demonstrated that daily doses of 500-1,500mg of berberine provide therapeutic benefits but remain well tolerated.46 12 But remember, many berberine supplements dont really contain the dose printed on the label, so the efficacy is closely tied to the brands safety measures (i.e., third-party testing and certificates of analysis)

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Availability of Data and Material Data are available on request from the authors

The substantial benefits these medicines provide for diabetes control and weight management typically outweigh temporary side effects