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We included peer-reviewed randomized controlled trials, meta-analyses, and high-quality narrative or systematic reviews written in English that evaluated the effects of GLP-1 receptor agonists (liraglutide, semaglutide, or related analogues), as well as dual GIP/GLP-1 receptor agonists (such as tirzepatide), exercise training, or their combination on weight loss, body composition, metabolic, or cardiovascular outcomes in adults with obesity or type 2 diabetes

Figure 4

10.1016/j.tox.2021.152898 119 LiJ.WangC.YueL.ChenF.CaoX.WangZ

Qualified medical guidance should be sought before any consideration of use

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