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Hoboken, NJ: Wiley-Blackwell (2021)

Resveratrol, a polyphenolic stilbene, displays concentration-dependent biphasic actions, at low doses it can weakly mimic estrogenic effects via ER activation, whereas at higher pharmacologic concentrations it acts as an ER antagonist, inhibits aromatase transcription, and disrupts co-activator recruitment to the ER complex, thereby exerting anti-proliferative and pro-apoptotic effects in ER-positive breast cancer cells (192)

Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide

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However, the molecular basis for how individual agonists can promote profound differences in pharmacology is still poorly understood