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Indicate that: After 1 half-life, 50% of the drug is gone

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In a double-blind, placebo-controlled study, a total of 1246 patients with mild to moderate hypertension received treatments of 2 combinations of amlodipine and valsartan (10 mg/160 mg, 10 mg/320 mg), or amlodipine alone (10 mg), valsartan alone (160 mg or 320 mg) or placebo

Much of it stays in the digestive tract, where it can cause a laxative effect

Early animal studies published in the *Journal of Endocrinology* showed that AOD-9604 could stimulate lipolysis (fat breakdown) and inhibit lipogenesis (fat creation) in obese Zucker rats

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