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If dopamine agonists are discontinued, they should be tapered off gradually, otherwise severe withdrawal effects might ensue

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Guo M, Gu J, Teng F et al (2020) The efficacy and safety of combinations of SGLT2 inhibitors and GLP-1 receptor agonists in the treatment of type 2 diabetes or obese adults: a systematic review and meta-analysis

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Understanding how peptides work at the receptor level helps explain why this approach makes biological sense