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doi: 10.1146/annurev-physiol-022516-034339 83 KapralovAAYangQDarHHTyurinaYYAnthonymuthuTSKimRet al

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(Native, unmodified recombinant human IGF-1, sold as mecasermin/Increlex, is FDA-approved only for a narrow pediatric growth-failure indication and is chemically distinct from the LR3 analog.) In the US it is manufactured and sold almost exclusively as an unregulated "research chemical" labeled "not for human consumption," a labeling practice peptide vendors use to avoid marketing it as an unapproved drug

It was approved by the U.S

doi: 10.1289/ehp.5935