It is estimated that as many as half of diabetics have underlying NAFLD, with a higher risk of progression to NASH with fibrosis than non-diabetics
Are there any situations where smaller doses of GLP-1 meds make sense
Signs of genuine receptor desensitization True receptor desensitization presents differently
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In murine models, the activation of GLP-1 receptors within the VTA has been shown to attenuate the synaptic strength of the VTA-NAcc pathway,154 although GLP-1 receptor expression in VTA neurons is relatively sparse.155 Rat studies indicate that GLP-1 receptor activation in the VTA can enhance dopaminergic neuronal activity via presynaptic mechanisms.156 Despite preclinical evidence and limited clinical trials, the precise influence of GLP-1 receptor stimulation on the effects of abused drugs and alcohol remains unclear
Various strategies are used to extend the half-lives of these agonists compared to native GLP-1 including using a synthetic analog of Ex4 (Byetta) and the addition of a fatty acid side chain to native GLP-1 to facilitate albumin binding (Liraglutide/Victoza)
