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Persistent CVB1 infection of PANC-1 cells upregulated type I IFN and immune response genes and induced differential expression of genes associated with the ECM, lysosomal biogenesis, cell-to-cell communication, and hormone secretion (147)

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Additionally, the immunological system can distinguish its own cells from foreign cells and acquire immune memory by remembering antigens it has encountered, which allows for faster and more effective action in times of threat

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46 Both SIRT1 and SIRT6 are found to be downregulated in older skin, and this correlates with a reduction in available NAD+