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Discussion In this model-based analysis of phase III randomized trials in individuals with T2DM, we observed that semaglutide and tirzepatide exhibit broadly comparable pharmacodynamic profiles for weight reduction when evaluated across clinically relevant dose ranges

Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat

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Discussion While the overall number of GLP-1 RA exposures increased during the study period, outcomes were largely benign, with the most common being no effect