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These nuclear receptors act as transcription factors rather than membrane receptors

Mice were maintained in a temperature-controlled room (2122 C) on a 12 hr light/dark cycle and supplied with food and water ad libitum

Nature 529 , 216220 (2016)

That can slow how the dose is used and is a known issue, particularly in women and larger patients where there is more tissue to pass through

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began taking a more assertive approach in 2012, when steroids from a Massachusetts compounding pharmacy led to hundreds of cases of meningitis and more than sixty deaths