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When used for this purpose, they may help people lose more than 10 to 15% Trusted Source PubMed Central Go to source of their body weight

PCOS (Polycystic Ovary Syndrome) How its suspected to work: - Reduces insulin resistance (a key driver of PCOS) - Promotes weight loss, which improves hormone balance - May lower testosterone and help regulate cycles - Reduces inflammation, which worsens symptoms Fatty Liver Disease (NAFLD/NASH) - Reduces liver fat by improving insulin sensitivity - Lowers inflammation and oxidative stress in liver cells - Helps with weight loss, which improves liver function Some GLP-1s are currently in trials for direct liver health benefits

J Biol Chem 241:814821 Kuroshima A, Yahata T (1979) Thermogenic responses of brown adipocytes to noradrenaline and glucagon in heat-acclimated and cold-acclimated rats

Interestingly, ursodeoxycholic acid, the only treatment approved by the Food and Drug Administration for the treatment of primary biliary cirrhosis, a chronic cholestatic disorder, was shown to prevent the fall in GCL expression during chronic cholestasis (Serviddio et al., 2004) and increase GCL expression in cultured rat hepatocytes (Mitsuyoshi et al., 1999)

The abdomen, front of thigh or outer upper arm can be used as may be convenient or comfortable